Tissue fragments, to be differentiated from groups, clumps or clusters that often result from centrifugation and other concentration artifacts, were strongly associated with urothelial neoplasia, uncommonly with nonneoplastic disease processes affecting the urinary tract but always with urothelial disease. OBJECTIVE To determine the diagnostic significance of tissue fragments in voided urine. The results of the present investigation using the Millipore filter technique for voided urine cytology processing, differed from those of a recently published study that employed cytocentrifugation. Tissue fragments, to be differentiated from groups, clumps or clusters that often result from centrifugation and other concentration artifacts, were strongly associated with urothelial neoplasia, uncommonly with nonneoplastic disease processes affecting the urinary tract but always with u rothelial disease. Proper identification of tissue fragments was highly significant and correlated with urothelial neoplastic changes. Three-dimensional groups were also statistically more common in cases with invasive transitional cell carcinoma. Tissue fragments, to be differentiated from groups, clumps or clusters that often result from centrifugation and other concentration artifacts, were strongly. 005) in urine specimens with biopsies revealing urothelial malignancies than in negative biopsies (6%). BACKGROUND:The presence of urothelial tissue fragments (UTF) in voided urine (VU) is often considered an abnormal finding that may be associated with the presence of urothelial papillary neoplasms. Cell groups (tissue fragments) consisting of either flat sheets or three-dimensional structures were significantly more common (57%) (chi 2 P <. Is White tissue like substance in urine your major concern Solve your problem quick & easy with online consultation. Of the 2,553 voided urine specimens examined, 174 (7%) had corresponding biopsies. An abnormal number (more than one per high-power field hpf) may be found in a wide variety of clinical conditions, including shock, trauma, burn, and exposure to toxins. The type and number of tissue fragments were correlated with the histologic diagnosis and clinical features the results were compared to those from a recently published study. Collecting duct cells in urine may be seen in very low numbers in normal individuals, but these cells are significant when found with renal casts and or as fragments. We reviewed all the voided urine specimens collected and processed by the Millipore filter technique (Bedford, Massachusetts, U.S.A.) at our institution between January 1, 1997, and December 31, 1998, and the corresponding biopsies obtained within 120 days after urine examination. If successful, non-invasive method could transform detection and treatment outcomes. To determine the diagnostic significance of tissue fragments in voided urine specimens. TGen-led study confirms cell-free DNA in urine as potential method for cancer detection.
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